Theradex® maintains a touch-tone automated voice response system for 24-hour patient registration and randomization. All calls are validated by the authentication of a project associated Personal Identification Number in order to ensure appropriate restriction of system access. A coupled, automated fax system generates paper confirmations in parallel with email notifications of each completed call. Eligibility requirements and randomization algorithms are custom-programmed for each study. In addition to allowing for global randomization capabilities without the hassle of preparing and distributing elaborate code lists and sealed envelopes for site pharmacies to decode, Therand® allows for organized assignment of patients to the appropriate treatment cohorts in dose escalation studies while allowing the study sponsor to have up-to-the-minute information on patient accrual 24 hours a day.